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December 1, 1997AJP Heart and Circulatory Physiology

Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes

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Population

Rat cultured heart cells (phenylephrine-induced hypertrophy model)

Comparison

Bradykinin and Perindoprilat vs Phenylephrine alone and co-administration with…

Design

Preclinical

Authors

YIYutaka IshigaiDaiichi-Sankyo (Japan)TMTomohiro MoriToyama Industrial Technology CenterTIToshiko IkedaNihon University

Discussion

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Implication

Supports bradykinin-NO mediation in rat cardiomyocytes; leaves open translation to human hypertrophy therapy.

Structured PICO

P
Population
Rat cultured heart cells (phenylephrine-induced hypertrophy model)
I
Intervention
Bradykinin (0.1, 1 nM) and Perindoprilat (1 microM)
C
Comparator
Phenylephrine alone (implied) and co-administration with HOE-140, N omega-nitro-L-arginine, or methylene blue
O
Outcome
Protein/DNA content (index of hypertrophy) and nitrite/nitrate content in the mediumsurrogate

Perindoprilat prevents cardiac hypertrophy in rat cardiomyocytes by stimulating the bradykinin-nitric oxide pathway.

Cite This Study

Ishigai et al. (1997) studied this question.

synapsesocial.com/papers/6a76e76ff6749a0058ec3aa6https://doi.org/10.1152/ajpheart.1997.273.6.h2659
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A specific B2‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril1992 · 236 citations
  2. 2Nitric oxide attenuates cardiac myocyte contraction1993 · 410 citations
  3. 3Nitric Oxide–Generating Compounds Inhibit Total Protein and Collagen Synthesis in Cultured Vascular Smooth Muscle Cells1995 · 281 citations
  4. 4Lack of correlation of hypotensive effects with prevention of cardiac hypertrophy by perindopril after ligation of rat coronary artery1994 · 20 citations
  5. 5Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis.1994 · 242 citations