Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 26, 2005AJP Heart and Circulatory Physiology

Transcriptional analysis of doxorubicin-induced cardiotoxicity

View Full Paper
Ask AI
Bookmark
Share

Population

Mice models of doxorubicin cardiotoxicity

Design

Preclinical

Follow-up

12 weeks (chronic model)

Authors

XYXiaoming YiIllinois Institute of TechnologyRBRaffi BekeredjianInterventional CardiologyNDNicholas J. DeFilippisThe University of Texas Southwestern Medical Center

Discussion

Loading...

Member takes

Overview

No immediate clinical implications for doxorubicin cardiotoxicity; hypothesis-generating and requires human validation before translation.

Structured PICO

P
Population
Mice models of doxorubicin cardiotoxicity
I
Intervention
Doxorubicin (acute model: 15 mg/kg once; chronic model: 3 mg/kg weekly for 12 weeks)
O
Outcome
Transcriptional regulation using muscle-specific cDNA microarray and left ventricular function via echocardiographysurrogate

Identified specific dysregulated genes (STARS, SNF1-kinase, AXUD1) in a chronic mouse model of doxorubicin-induced cardiomyopathy, providing insights into mechanisms of cardiotoxicity.

Cite This Study

Yi et al. (2005) studied this question.

synapsesocial.com/papers/6a76e91e6789de8d0af6e487https://doi.org/10.1152/ajpheart.00832.2005
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin Cardiomyopathy2003 · 220 citations
  2. 2Apoptosis in Adriamycin Cardiomyopathy and Its Modulation by Probucol2001 · 160 citations
  3. 3Fas-Mediated Apoptosis in Adriamycin-Induced Cardiomyopathy in Rats2000 · 223 citations
  4. 4AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge1999 · 354 citations
  5. 5STARS, a Striated Muscle Activator of Rho Signaling and Serum Response Factor-dependent Transcription2002 · 139 citations