Why the study?
Does selective ETA or ETB receptor blockade improve monocrotaline-induced pulmonary hypertension in rats?
Population
Rats treated with monocrotaline (MCT, 60 mg/kg, s.c.) to induce pulmonary hypertension
Comparison
Daily administration of A-192621, ABT-627, or a… vs Control animals and MCT-treated rats without…
Design
Preclinical
Follow-up
4 weeks
Authors
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Preclinical data indicate opposing ETA and ETB receptor roles in experimental pulmonary hypertension; leaves open selective ETA blockade as a therapeutic strategy in humans.
Does selective ETA or ETB receptor blockade improve monocrotaline-induced pulmonary hypertension in rats?
ETA receptor-mediated action contributes exclusively to the pathogenesis of MCT-induced pulmonary hypertension, while ETB receptor blockade aggravates it, suggesting a protective role for ETB receptors.
Nishida et al. (2004) studied this question.
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