What question did this study set out to answer?

To determine the role of central angiotensin II AT1 receptors on nocturnal baseline and angiotensin-stimulated water and sodium intake in ovariectomised rats with or without chronic estrogen replacement.

December 1, 2007Journal of the Renin-Angiotensin-Aldosterone System

Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats

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Population

Ovariectomised Wistar female rats

Comparison

Intracerebroventricular injection of losartan… vs Vehicle (for oestrogen) and baseline conditions

Design

Preclinical

Authors

AMAndré S. MecawiUniversidade Federal de São Paulo ALAilin LepletierGriffith University IAIracema AraújoUniversidade Federal Rural do Rio de Janeiro

Discussion

Member takes

Implication

Should not inform clinical fluid management; leaves open oestrogen modulation of brain AT1-dependent intake in humans.

Key Points

To determine the role of central angiotensin II AT1 receptors on nocturnal baseline and angiotensin-stimulated water and sodium intake in ovariectomised rats with or without chronic estrogen replacement.
Ovariectomised female Wistar rats received chronic treatment with either estrogen or vehicle.
Assessed nocturnal water and salt intake following intracerebroventricular microinjections of losartan, angiotensin I, or angiotensin II.
Central losartan administration decreased basal nocturnal water intake in ovariectomised rats.
Angiotensin II, but not angiotensin I, triggered nocturnal dipsogenic and natriorexigenic responses in ovariectomised rats, whereas estrogen replacement enabled both peptides to stimulate fluid intake.
Pretreatment with losartan completely abolished both angiotensin-induced fluid intake and basal nocturnal drinking across all groups.

Structured PICO

Population

Ovariectomised Wistar female rats

Intervention

Intracerebroventricular (i.c.v.) injection of losartan, Angiotensin I (Ang I), and Angiotensin II (Ang II), with or without chronic oestrogen replacement

Comparator

Vehicle (for oestrogen) and baseline conditions

Outcome

Nocturnal fluids intake (water and salt intake)surrogate

The brain AT1-receptor regulates nocturnal basal water and salt intake in ovariectomised rats, and oestrogen influences these brain RAS-dependent homeostatic behaviors.

Cite This Study

Mecawi et al. (2007) studied this question.

synapsesocial.com/papers/6a76eb183da069e66cbd6bf2 https://doi.org/10.3317/jraas.2007.032

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Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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