December 1, 1988Biochemistry
Tropomyosin inhibits the rate of actin polymerization by stabilizing actin filaments
Population
Actin filaments (in vitro basic science model)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May guide thin filament models in cardiac muscle; leaves open human disease relevance.
Structured PICO
P
Population
Actin filaments (in vitro basic science model)
I
Intervention
Tropomyosin (alpha alpha- and alpha beta-tropomyosin)
O
Outcome
Rate of spontaneous polymerization of actin and rate of elongationsurrogate
Tropomyosin inhibits actin polymerization by mechanically stabilizing filaments and reducing the number of filament ends, rather than affecting the elongation rate.
Cite This Study
Hitchcock‐DeGregori et al. (1988) studied this question.