Key result
A novel silicon photonics-based laser Doppler vibrometer array identified reliable fiducial points for pulse transit time calculation comparable to reference applanation tonometry.
Why the study?
Low-cost and easy-to-use pulse wave velocity measurement devices are needed for routine clinical practice to measure aortic stiffness as a biomarker of cardiovascular risk.
Does a silicon photonics-based laser Doppler vibrometer array reliably measure carotid-femoral pulse wave velocity compared to applanation tonometry in humans?
Does a silicon photonics-based laser Doppler vibrometer array reliably measure carotid-femoral pulse wave velocity compared to applanation tonometry in humans?
A novel silicon photonics-based laser Doppler vibrometer array demonstrates feasibility for measuring carotid-femoral pulse wave velocity, potentially enabling low-cost cardiovascular risk assessment.
Pulse wave velocity (PWV) is a reference measure for aortic stiffness, itself an important biomarker of cardiovascular risk. To enable low-cost and easy-to-use PWV measurement devices that can be used in routine clinical practice, we have designed several handheld PWV sensors using miniaturized laser Doppler vibrometer (LDV) arrays in a silicon photonics platform. The LDV-based PWV sensor design and the signal processing protocol to obtain pulse transit time (PTT) and carotid-femoral PWV in a feasibility study in humans, are described in this paper. Compared with a commercial reference PWV measurement system, measuring arterial pressure waveforms by applanation tonometry, LDV-based displacement signals resulted in more complex signals. However, we have shown that it is possible to identify reliable fiducial points for PTT calculation using the maximum of the 2 nd derivative algorithm in LDV-based signals, comparable to those obtained by the reference technique, applanation tonometry.
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Li et al. (2020) studied this question. Silicon photonics-based laser Doppler vibrometer (LDV) array vs. Applanation tonometry was evaluated on Pulse transit time (PTT) and carotid-femoral PWV calculation. A novel silicon photonics-based laser Doppler vibrometer array identified reliable fiducial points for pulse transit time calculation comparable to reference applanation tonometry.
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