July 12, 1965JAMA

Multiple Fractures Associated With Long-term Sodium Heparin Therapy

View Full Paper

Ask AI

Bookmark

Why the study?

Does long-term sodium heparin therapy cause multiple fractures in patients with coronary artery disease?

Population

41-year-old white male with angina pectoris without apparent myocardial infarction

Design

Case_report

Follow-up

13 months

Authors

Discussion

Raises possibility of heparin-related fractures during prolonged therapy; single case leaves open whether causal in CAD patients.

Does long-term sodium heparin therapy cause multiple fractures in patients with coronary artery disease?

Population

41-year-old white male with angina pectoris (coronary artery disease) without apparent myocardial infarction (n=1)

Intervention

Sodium heparin 20,000 units (approx 200 mg) deep subcutaneous injection nightly for 13 months (with a 20-day period of 280 mg nightly)

Outcome

Multiple fractures of vertebrae and ribssafety

Long-term sodium heparin therapy may be associated with a previously unrecognized complication of multiple bone fractures.

Martin D. Jaffe (1965) studied this question.

View Full Paper

Ask AI

Bookmark