Key result
Antenatal ligation of the arterial duct in ovine fetuses led to septal myocardial thickening, a 3.5° increase in myocyte angulation, and a 2.2% increase in right ventricular collagen content.
Population
Ovine fetuses (n=11; 6 with induced persistent pulmonary hypertension, 5 matched controls)
Comparison
Antenatal ligation of the arterial duct to… vs Matched control hearts
Design
Preclinical
Authors
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Highlights potential myocardial effects of fetal ductal ligation; leaves open human applicability in duct-dependent congenital heart disease.
In an ovine model of persistent pulmonary hypertension of the newborn, myocardial fibrosis and altered myocyte angulation were observed, providing potential structural explanations for heart failure in this syndrome.
Agger et al. (2015) studied Persistent pulmonary hypertension of the newborn (n=11). Antenatal ligation of the arterial duct vs. Matched control hearts was evaluated on Myocardial architecture changes (heart size, angulation of myocyte aggregations, collagen content). Antenatal ligation of the arterial duct in ovine fetuses led to septal myocardial thickening, a 3.5° increase in myocyte angulation, and a 2.2% increase in right ventricular collagen content.
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