Why the study?
Does propofol attenuate beta-adrenoreceptor-mediated signal transduction in isolated ventricular myocytes?
Does propofol attenuate beta-adrenoreceptor-mediated signal transduction in isolated ventricular myocytes?
Clinically relevant concentrations of propofol attenuate beta-adrenergic signal transduction in cardiac myocytes via a PKC-alpha-dependent inhibition of cAMP production upstream of adenylyl cyclase.
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Propofol may blunt beta-adrenergic responses in myocytes via PKC; leaves open clinical relevance during anesthesia.
Kurokawa et al. (2002) studied this question.
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