Why the study?
Does losartan improve baroreflex sensitivity and heart rate variability compared to atenolol in subjects with uncomplicated essential hypertension?
Population
30 subjects with uncomplicated essential hypertension
Comparison
Losartan 50 mg to 100 mg daily for 6 months vs Atenolol 50 mg to 100 mg daily for 6 months
Design
RCT, randomized
Follow-up
6 months
Authors
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Losartan may confer autonomic advantages over atenolol in hypertension; extends ARB evidence beyond BP reduction and supports outcome trials.
Does losartan improve baroreflex sensitivity and heart rate variability compared to atenolol in subjects with uncomplicated essential hypertension?
Losartan demonstrates superior effects on baroreflex sensitivity and heart rate variability compared to atenolol in uncomplicated essential hypertension, suggesting benefits beyond blood pressure reduction.
Chern et al. (2006) studied this question.
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