Population
Human DNA polymerases isolated from HeLa S3 cells, and human Molt-4 cells in culture.
Design
Preclinical
Follow-up
up to 7 days
Authors
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Inhibition of isolated DNA polymerases may not predict nucleoside analog mitochondrial toxicity; leaves open need for direct mtDNA synthesis assays in preclinical screening.
Inhibition of isolated DNA polymerases by antiviral nucleoside analogs may not accurately predict in vitro or in vivo toxicity related to mitochondrial DNA synthesis.
Martin et al. (1994) studied this question.
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