Summarizes basic science laboratory investigations on DNA polymerase substrates used to design novel antiviral nucleotides.
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May guide antiviral nucleotide design in vitro; leaves open clinical translation and efficacy.
The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.
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Krayevsky et al. (1996) studied this question.
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