Key result
Antiviral agents targeting viral DNA and RNA polymerases are reviewed, summarizing chemically synthesized and natural product inhibitors and proposing promising development strategies.
Why the study?
Viral polymerases are relatively conserved favorable targets for antiviral development with structural similarities that enable universal inhibition across viruses.
This review highlights the development and potential of viral polymerase inhibitors as broad-spectrum antiviral agents.
Answers are grounded in this paper and cite their sources.
May guide pan-viral polymerase inhibitor design; leaves open prospective efficacy trials across virus families.
Viral DNA and RNA polymerases are two kinds of very important enzymes that synthesize the genetic materials of the virus itself, and they have become extremely favorable targets for the development of antiviral drugs because of their relatively conserved characteristics. There are many similarities in the structure and function of different viral polymerases, so inhibitors designed for a certain viral polymerase have acted as effective universal inhibitors on other types of viruses. The present review describes the development of classical antiviral drugs targeting polymerases, summarizes a variety of viral polymerase inhibitors from the perspective of chemically synthesized drugs and natural product drugs, describes novel approaches, and proposes promising development strategies for antiviral drugs.
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Peng et al. (2022) conducted a review in Viral infections. Antiviral agents targeting viral polymerases was evaluated. Antiviral agents targeting viral DNA and RNA polymerases are reviewed, summarizing chemically synthesized and natural product inhibitors and proposing promising development strategies.
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