Key result
In patients with ischemic heart disease, elevated C-reactive protein levels (>0.08 mg/dL) were associated with a significantly increased high frequency component of brachial artery vasomotion compared to low CRP levels (0.052 vs 0.035, p<0.05).
Observational (n=37)
No
The high-frequency component of brachial artery vasomotion correlates with endothelial dysfunction and elevated CRP in patients with ischemic heart disease, suggesting it may serve as a novel marker of vascular injury.
Elevated CRP links to altered brachial vasomotion; hypothesis-generating for high-frequency component as endothelial marker, needs prospective validation.
PURPOSE: The physiological role of vasomotion, rhythmic oscillations in vascular tone or diameter, and its underlying mechanisms are unknown. We investigated the characteristics of brachial artery vasomotion in patients with ischemic heart disease (IHD). METHODS: We performed a retrospective study of 37 patients with IHD. Endothelial function was assessed using flow-mediated dilation (FMD), and power spectral analysis of brachial artery diameter oscillations during FMD was performed. Frequency-domain components were calculated by integrating the power spectrums in three frequency bands (in ms2) using the MemCalc (GMS, Tokyo, Japan): very-low frequency (VLF), 0.003-0.04 Hz; low frequency (LF), 0.04-0.15 Hz; and high frequency (HF), 0.15-0.4 Hz. Total spectral power (TP) was calculated as the sum of all frequency bands, and each spectral component was normalized against TP. RESULTS: Data revealed that HF/TP closely correlated with FMD (r = -0.33, p = 0.04), whereas VLF/TP and LF/TP did not. We also explored the relationship between elevated C-reactive protein (CRP) levels and vasomotion. HF/TP was significantly increased in subjects with high CRP levels (CRP;>0.08 mg/dL) compared with subjects with low CRP levels (0.052±0.026 versus 0.035±0.022, p<0.05). The HF/TP value closely correlated with CRP (r = 0.24, p = 0.04), whereas the value of FMD did not (r = 0.023, p = 0.84). In addition, elevated CRP levels significantly increased the value of HF/TP after adjustment for FMD and blood pressure (β = 0.33, p<0.05). CONCLUSION: The HF component of brachial artery diameter oscillation during FMD measurement correlated well with FMD and increased in the presence of elevated CRP levels in subjects with IHD.
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Watanabe et al. (2014) conducted an observational in Ischemic heart disease (n=37). Elevated C-reactive protein (>0.08 mg/dL) vs. Low C-reactive protein (≤0.08 mg/dL) was evaluated on High frequency to total spectral power ratio (HF/TP) of brachial artery vasomotion (p=<0.05). In patients with ischemic heart disease, elevated C-reactive protein levels (>0.08 mg/dL) were associated with a significantly increased high frequency component of brachial artery vasomotion compared to low CRP levels (0.052 vs 0.035, p<0.05).
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