Why the study?
Does perindopril compared to losartan improve plasma PAI-1 and fibrinogen in hypertensive type 2 diabetic patients?
Population
85 nonsmoking outpatients, aged 46 to 64 years, with mild to moderate essential hypertension and well…
Comparison
Perindopril 4 mg once daily for 12 weeks vs Losartan 50 mg once daily for 12 weeks
Design
RCT, randomized, double-blind, parallel-group design
Follow-up
12 weeks
Authors
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Perindopril may be preferred over losartan for PAI-1 reduction in hypertensive T2D; extends ACEI-specific effects on fibrinolysis.
Does perindopril compared to losartan improve plasma PAI-1 and fibrinogen in hypertensive type 2 diabetic patients?
Perindopril, but not losartan, significantly reduces plasma PAI-1 levels in hypertensive patients with type 2 diabetes, suggesting differential effects on endothelial function or the bradykinin system.
Fogari et al. (2002) studied this question.
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