Key result
COX-2 inhibition with celecoxib resulted in lower resting SBP (p<0.001) and DBP (p=0.02) in females compared to males, and increased SBP response to AngII in females (p=0.039).
Why the study?
Animal studies suggest greater vascular dependence on prostaglandins in females, but whether this extends to humans was unknown.
Does celecoxib 200 mg daily affect blood pressure and arterial stiffness differently in healthy females compared to males?
Does celecoxib 200 mg daily affect blood pressure and arterial stiffness differently in healthy females compared to males?
COX-2 inhibition with celecoxib may have sex-specific effects on arterial function and blood pressure response, highlighting the need for sex-specific cardiovascular risk assessment with NSAIDs.
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COX-2 inhibition may raise SBP more in premenopausal females; leaves open sex-specific prostaglandin dependence for prospective study.
Rytz et al. (2022) studied Healthy adults (n=24). Celecoxib vs. Baseline (pre-COX-2 inhibition) was evaluated on Blood pressure and pulse-wave velocity (PWV) at baseline and in response to an Angiotensin II (AngII) challenge. COX-2 inhibition with celecoxib resulted in lower resting SBP (p<0.001) and DBP (p=0.02) in females compared to males, and increased SBP response to AngII in females (p=0.039).
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