Key result
High-resolution computational fluid dynamics simulations showed poor correlations with normal-resolution strategies in the left atrial appendage for OSI, RRT, and ECAP.
Why the study?
Despite sophisticated computational fluid dynamics studies of left atrial flows, little focus has been placed on fundamental fluid modeling of these flows.
High-resolution computational fluid dynamics (10 M elements, 10 k time-steps per cycle) is necessary to robustly predict left atrial hemodynamics and stresses.
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NR simulations may misestimate LAA thrombotic indices; leaves open whether high-resolution CFD is required for reliable atrial hemodynamics research.
Khalili et al. (2024) studied Left atrial flows (n=12). High-resolution (HR) solution strategies vs. Normal-resolution/accuracy (NR) solution strategies was evaluated on Spatiotemporal convergence and differences in wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT), and endothelial cell activation potential (ECAP). High-resolution computational fluid dynamics simulations showed poor correlations with normal-resolution strategies in the left atrial appendage for OSI, RRT, and ECAP.
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