May 13, 1997Proceedings of the National Academy of SciencesOpen Access

Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells

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Structured PICO

Population

MA104 monkey kidney cells and Caco-2 human colonic adenocarcinoma cells infected with RV-5 rotavirus (serotype G2P1B) or SA11 virus (serotype G3P[2])

Intervention

Synthetic peptides containing integrin ligand motifs (RDGEE, GPRP, LDVT) and monoclonal antibodies against integrins (anti-alpha2, anti-beta2, anti-alpha4)

Comparator

Sequence-related control peptides (e.g., RAGEE, RGES, RGD) and irrelevant isotype-matched control mAbs

Outcome

Rotavirus infectivity measured by fluorescent focus reduction assaysurrogate

Rotavirus outer capsid proteins VP4 and VP7 contain integrin ligand sequences that mediate cell entry via alpha2beta1, alphaxbeta2, and alpha4beta1 integrins.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Integrin blockade remains investigational for rotavirus; animal data leave open clinical translation and human efficacy.

Cite This Study

Coulson et al. (1997) studied this question.

synapsesocial.com/papers/6a7715093da069e66cbd7c5b https://doi.org/10.1073/pnas.94.10.5389

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Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells

Structured PICO

Discussion

Implication

Cite This Study

Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider