Population
MA104, Caco-2, and CHO cell lines expressing wild-type or mutated human alpha2 or alpha2beta1 integrins
Comparison
Simian rotavirus SA11 and rhesus rotavirus RRV vs Human rotavirus Wa; anti-alpha2 I domain MAbs vs…
Design
Preclinical
Authors
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May guide rotavirus entry inhibitor development; leaves open human translation from animal cell models.
Simian and rhesus rotaviruses require the alpha2 I domain for binding to alpha2beta1 integrin, facilitating infection and growth.
Londrigan et al. (2003) studied this question.
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