Why the study?
Does the NO donor SNAP regulate PDGF-induced activation of PKB and ERK in A7r5 vascular smooth muscle cells?
Does the NO donor SNAP regulate PDGF-induced activation of PKB and ERK in A7r5 vascular smooth muscle cells?
Prolonged exposure to nitric oxide attenuates PDGF-induced PKB-alpha activation, contributing to diminished vascular smooth muscle cell proliferation via growth arrest rather than apoptosis.
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May guide mechanistic research on VSMC growth arrest; leaves open relevance to human vascular disease.
Sandirasegarane et al. (2000) studied this question.
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