Population
In vitro biochemical assays using fluorogenic caspase-1 substrate and Bradykinin-analog peptides to…
Comparison
SARS-CoV-2 trimeric spike protein and its… vs Baseline ACE2 activity without SARS-CoV-2 spike…
Design
Preclinical
Authors
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May link spike-ACE2 interaction to vascular complications; hypothesis-generating in animals, needs human validation before clinical consideration.
SARS-CoV-2 spike protein binding significantly enhances ACE2 proteolytic activity, providing potential mechanistic insights into the pathogenesis and vascular complications of COVID-19.
Halliday et al. (1964) studied this question.
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