Key result
Women taking oral contraceptives had higher 24-h blood pressure and a higher Ang II/Ang (1-7) ratio compared to ovulatory women (P<0.01).
Why the study?
Does oral contraceptive use alter the Angiotensin II/Angiotensin (1-7) ratio and 24-h blood pressure compared to normal ovulatory cycles in healthy women?
Population
30 healthy, normotensive women aged 18-30 years (n=15 ovulatory, n=15 taking oral contraceptives)
Comparison
Oral contraceptive use vs Normal ovulatory cycle
Design
Cross-sectional
Authors
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May warrant BP monitoring in oral contraceptive users; leaves open whether angiotensin imbalance contributes to hypertension risk.
Observational (n=30)
Does oral contraceptive use alter the Angiotensin II/Angiotensin (1-7) ratio and 24-h blood pressure compared to normal ovulatory cycles in healthy women?
p-value: p=<0.01
Oral contraceptive use in healthy women is associated with higher 24-h blood pressure and an altered Angiotensin II/Angiotensin (1-7) ratio compared to normal ovulatory cycles, though a direct causal relationship was not established.
Davis et al. (2017) conducted an observational in Healthy, normotensive (n=30). Oral contraceptives vs. Ovulatory women was evaluated on 24-h blood pressure and Ang II/Ang (1-7) ratio (p=<0.01). Women taking oral contraceptives had higher 24-h blood pressure and a higher Ang II/Ang (1-7) ratio compared to ovulatory women (P<0.01).
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