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October 14, 2015BMJ Case ReportsOpen Access

Hypertriglyceridaemia unresponsive to multiple treatments

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Key result

A 'glycerol blank' test revealed a true triglyceride value of 0.7 mmol/L compared to an apparent value of 7 mmol/L, diagnosing pseudohypertriglyceridaemia due to glycerol kinase deficiency.

Population

1 52-year-old man with a longstanding history of hypertriglyceridaemia (approximately 7 mmol/L) unresponsive…

Design

Case_report

Authors

JBJames M. BackesTDThomas DayspringDHDaniel M Hoefner

Discussion

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Overview

May prompt glycerol blank testing for discrepant triglycerides; leaves open broader prevalence and screening utility of glycerol kinase deficiency.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 52-year-old man with a longstanding history of apparent hypertriglyceridaemia unresponsive to treatment.
E
Exposure
Discontinuation or modification of primary triglyceride-lowering agents after diagnosis of pseudohypertriglyceridaemia
O
Outcome
True triglyceride value measured via 'glycerol blank'surrogate

Pseudohypertriglyceridaemia due to glycerol kinase deficiency should be suspected in patients with refractory hypertriglyceridaemia and clear serum to avoid unnecessary treatment.

Cite This Study

Backes et al. (2015) conducted a case report in Hypertriglyceridaemia (n=1). Glycerol blank testing was evaluated on Triglyceride value. A 'glycerol blank' test revealed a true triglyceride value of 0.7 mmol/L compared to an apparent value of 7 mmol/L, diagnosing pseudohypertriglyceridaemia due to glycerol kinase deficiency.

synapsesocial.com/papers/6a772010d2fa2470761ea91ehttps://doi.org/10.1136/bcr-2015-210788
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identifying pseudohypertriglyceridemia in clinical practice2014 · 20 citations
  2. 2Glycerol Metabolism and the Determination of Triglycerides –Clinical, Biochemical and Molecular Findings in Six Subjects2003 · 21 citations
  3. 3Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines2004 · 6,934 citations
  4. 4Isolated and contiguous glycerol kinase gene disorders: A review2000 · 71 citations
  5. 5Familial hyperglycerolemia.1978 · 58 citations