Peptide mapping demonstrates structural homology between active and inactive human renin, supporting the existence of a renin zymogen.
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No immediate clinical implications; leaves open whether renin zymogen affects human cardiovascular outcomes.
Data obtained from peptide mapping of the active and inactive forms of human renin show that there are extensive regions of common sequence in the two forms of the enzyme, and are consistent with the hypothesis that inactive renin is a renin zymogen.
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McIntyre et al. (1984) studied this question.
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