Key result
The SI strain of measles virus derived from an SSPE patient exhibited altered receptor specificity and limited fusion activity due to specific amino acid substitutions in the F and H proteins.
Population
SI strain of measles virus isolated in 1976 from a patient with Subacute Sclerosing Panencephalitis and…
Comparison
Recombinant SI strain expressing a green… vs Wild-type measles virus (MV) strain
Design
Preclinical
Authors
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May restrict SSPE viral spread; leaves open translational relevance of F/H substitutions in humans.
The SI strain of measles virus from an SSPE patient exhibits altered receptor specificity and limited fusion activity due to specific amino acid substitutions in the F and H proteins.
Seki et al. (2011) studied Subacute sclerosing panencephalitis (SSPE). Recombinant SI strain of measles virus vs. Wild-type measles virus strain was evaluated on Viral growth phenotype, receptor specificity, and membrane fusion activity. The SI strain of measles virus derived from an SSPE patient exhibited altered receptor specificity and limited fusion activity due to specific amino acid substitutions in the F and H proteins.
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