Key result
The M protein of the SSPE virus Kobe-1 strain, synergistically with the F protein, is indispensable for viral neuropathogenicity and enhanced cell-cell fusion.
Why the study?
The mechanism by which SSPE virus Kobe-1 strain M protein supports F protein fusion activity and cooperatively induces neurovirulence remained unclear.
Population
Mice
Authors
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SSPE M protein defects remain incompletely characterized; leaves open their precise contribution to CNS persistence.
The M protein of the SSPE virus Kobe-1 strain synergistically enhances the fusion activity of the F protein to induce neurovirulence, providing a mechanism for SSPE pathogenesis.
Satoh et al. (2021) studied Subacute sclerosing panencephalitis (SSPE). Recombinant chimeric measles viruses (Kobe-1 strain M and F genes) vs. Wild-type measles virus (ICB strain) and other chimeric variants was evaluated on Neuropathogenicity (mortality in suckling mice) and cell-cell fusion. The M protein of the SSPE virus Kobe-1 strain, synergistically with the F protein, is indispensable for viral neuropathogenicity and enhanced cell-cell fusion.