Key result
Preoperative SUVmax > 4.5 on 18F-FDG PET/CT was highly predictive of FNCLCC grade 3 and significantly associated with worse overall survival (HR 5.052) in patients with retroperitoneal liposarcoma.
Why the study?
While 18F-FDG PET/CT has been investigated in extremity sarcomas, evidence on its usefulness in retroperitoneal sarcoma is lacking.
Does preoperative SUVmax on 18F-FDG PET/CT predict tumor aggressiveness and survival in patients with retroperitoneal liposarcoma?
Population
133 patients undergoing surgery for retroperitoneal liposarcoma with preoperative 18F-FDG PET/CT
Comparison
Preoperative SUVmax on 18F-FDG PET/CT
Design
Retrospective cohort study
Authors
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May refine preoperative risk stratification in retroperitoneal liposarcoma; leaves open whether it changes management or outcomes.
Cohort (n=133)
No
Does preoperative SUVmax on 18F-FDG PET/CT predict tumor aggressiveness and survival in patients with retroperitoneal liposarcoma?
Hazard Ratio: 5.052 (95% CI 1.854–13.766)
p-value: p=0.002
Preoperative SUVmax > 4.5 on 18F-FDG PET/CT is highly predictive of high-grade tumor and poor survival in patients with retroperitoneal liposarcoma, which can aid in surgical planning.
Rhu et al. (2019) conducted a cohort in Retroperitoneal liposarcoma (n=133). Maximum standardized uptake value (SUVmax) > 4.5 on 18F-FDG PET/CT vs. SUVmax ≤ 4.5 was evaluated on Overall survival (HR 5.052, 95% CI 1.854-13.766, p=0.002). Preoperative SUVmax > 4.5 on 18F-FDG PET/CT was highly predictive of FNCLCC grade 3 and significantly associated with worse overall survival (HR 5.052) in patients with retroperitoneal liposarcoma.
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