Key result
Preoperative PET/CT metabolic tumor volume above ~458 is linked to overall survival in retroperitoneal liposarcoma.
Why the study?
Does volume-based 18F-FDG PET/CT predict clinical, prognostic, and pathological factors in patients with retroperitoneal liposarcoma?
Cohort (n=89)
Blinded assessors
No
Does volume-based 18F-FDG PET/CT predict clinical, prognostic, and pathological factors in patients with retroperitoneal liposarcoma?
p-value: p=0.025
Volume-based 18F-FDG PET/CT parameters, specifically metabolic tumor volume, are significantly associated with pathological features and overall survival in retroperitoneal liposarcoma, aiding surgical strategy.
MTV may refine preoperative risk stratification in retroperitoneal liposarcoma; hypothesis-generating for PET/CT-guided decisions pending prospective validation.
PURPOSE: F-FDG PET/CT may solve this issue. METHODS: We analyzed data from 89 RLPS patients, measuring metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) and explored their associations with clinical, prognostic, and pathological factors. RESULTS: MTV, TLG of multifocal and recurrent RLPS were significantly higher than unifocal and primary ones (P < 0.001, P < 0.001, P = 0.003 and P = 0.002, respectively). SUVmax correlated with FNCLCC histological grade, mitotic count and Ki-67 index (P for G1/G2 = 0.005, P for G2/G3 = 0.017, and P for G1/G3 = 0.001, P < 0.001 and P = 0.024, respectively). MTG, TLG and SUVmax of WDLPS were significantly lower than DDLPS and PLPS (P for MTV were 0.009 and 0.022, P for TLG were 0.028 and 0.048, and P for SUVmax were 0.027 and < 0.001, respectively). Multivariable Cox analysis showed that MTV > 457.65 (P = 0.025), pathological subtype (P = 0.049) and FNCLCC histological grade (P = 0.033) were related to overall survival (OS). CONCLUSIONS: F-FDG PET/CT offers valuable information to aid in the decision-making process for RLPS surgical strategies.
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Liu et al. (2023) conducted a cohort in Retroperitoneal Liposarcoma (RLPS) (n=89). Metabolic tumor volume (MTV) > 457.65 on 18F-FDG PET/CT vs. MTV < 457.65 was evaluated on Overall survival (OS) (p=0.025). Metabolic tumor volume (MTV) greater than 457.65 measured by preoperative 18F-FDG PET/CT was an independent prognostic factor for overall survival in patients with retroperitoneal liposarcoma.
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