Key result
In Korean men with cardiovascular risk factors, a low HDL-C level (<30 mg/dl) was independently associated with a 38% increased risk of ischemic heart disease compared to levels ≥60 mg/dl (HR 1.38).
Why the study?
Do elevated triglycerides and reduced HDL-C independently increase the risk of ischemic heart disease in Korean men with cardiovascular risks?
Cohort (n=29,171)
Yes
Do elevated triglycerides and reduced HDL-C independently increase the risk of ischemic heart disease in Korean men with cardiovascular risks?
Elevated triglycerides and reduced HDL-C are independent risk factors for ischemic heart disease in Korean men with cardiovascular risk factors.
Low HDL-C signals higher IHD risk in Korean men with CV factors; leaves open whether raising HDL-C improves outcomes.
BACKGROUND: Although many epidemiological studies have suggested that a decreased level of high-density lipoprotein-cholesterol (HDL-C) is a risk factor for heart disease; this relationship remains uncertain in relation to triglycerides (TG). This study examined the effects of serum TG and HDL-C on the incidence of ischemic heart disease (IHD) in Korean men. METHODS AND RESULTS: A 14-year prospective cohort study was carried out with 29,171 Korean men who received insurance from the National Health Insurance Corporation and underwent a second screening for their cardiovascular risks. The main outcome measures were incidence of IHD. During 379,539 person-years of follow-up, 1,634 IHD (227 fatal IHD) events occurred. In the age-adjusted models, men in the lowest level of HDL-C (<30 mg/dl) showed a higher risk [hazard ratio (HR) 1.57; 95% confidence interval (CI) 1.26-1.95] when compared with men with the highest concentration (HDL-C > or =60 g/dl), defined as the reference group. When TG were included in the multivariate adjusted Cox model, the relationship of HDL-C with IHD was weakened but remained (HR 1.38; 95%CI 1.10-1.73). The results were similar for TG in the multivariate model including HDL-C. CONCLUSIONS: These findings indicate that elevated TG and reduced HDL-C are independent risk factors for IHD risk in Korean men with cardiovascular risks.
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Linton et al. (2009) conducted a cohort in Cardiac risk factors (n=29,171). Low HDL-C (<30 mg/dl) vs. High HDL-C (≥60 mg/dl) was evaluated on Incidence of ischemic heart disease (IHD) (HR 1.38, 95% CI 1.10-1.73). In Korean men with cardiovascular risk factors, a low HDL-C level (<30 mg/dl) was independently associated with a 38% increased risk of ischemic heart disease compared to levels ≥60 mg/dl (HR 1.38).
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