Key result
The highest quartile of the triglyceride-glucose index was associated with a 2.29-fold increased risk of incident ischemic heart disease compared to the lowest quartile in nondiabetic Korean adults.
Why the study?
Ischemic heart disease without diabetes poses a major health challenge and is associated with poor prognosis and low health awareness, prompting investigation into the predictive role of the triglyceride-glucose index.
Does a higher triglyceride-glucose (TyG) index predict incident ischemic heart disease in nondiabetic Korean adults?
Population
16,455 nondiabetic Korean adults
Comparison
TyG index quartiles
Design
Prospective cohort study
Follow-up
50-month period
Authors
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May identify higher IHD risk in nondiabetics; hypothesis-generating and should not yet change practice.
Cohort (n=16,455)
No
Does a higher triglyceride-glucose (TyG) index predict incident ischemic heart disease in nondiabetic Korean adults?
Hazard Ratio: 2.29 (95% CI 1.5–3.51)
Absolute Event Rate: 12.1% vs 4.2%
p-value: p=0.001
An elevated triglyceride-glucose (TyG) index is an independent predictor of incident ischemic heart disease in nondiabetic adults, suggesting its utility as a preclinical cardiovascular risk marker.
Park et al. (2020) conducted a cohort in Nondiabetic adults at risk for ischemic heart disease (n=16,455). Triglyceride-glucose (TyG) index vs. Lowest TyG index quartile was evaluated on Incident ischemic heart disease (HR 2.29, 95% CI 1.50-3.51, p=0.001). The highest quartile of the triglyceride-glucose index was associated with a 2.29-fold increased risk of incident ischemic heart disease compared to the lowest quartile in nondiabetic Korean adults.
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