Key result
An increased triglyceride to HDL-cholesterol ratio in the highest quartile was associated with a 2.29-fold higher risk of incident ischemic heart disease compared to the lowest quartile in Koreans without diabetes.
Why the study?
Early insulin resistance without diabetes can cause cardiovascular disease, but the effects of the triglyceride to high-density lipid-cholesterol ratio on incident ischemic heart disease risk needed investigation.
Does an increased TG/HDL-C ratio predict incident ischemic heart disease in individuals without diabetes?
Population
16,455 individuals (8,426 men and 8,029 women) without diabetes in a community-dwelling Korean cohort
Comparison
TG/HDL-C quartiles
Design
Prospective longitudinal cohort study
Follow-up
50 months
Authors
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May inform IHD risk assessment via TG/HDL-C in nondiabetics; leaves open whether targeting the ratio alters outcomes.
Cohort (n=16,455)
No
Does an increased TG/HDL-C ratio predict incident ischemic heart disease in individuals without diabetes?
Hazard Ratio: 2.29 (95% CI 1.5–3.51)
p-value: p=<0.001
An increased TG/HDL-C ratio is a significant predictor of incident ischemic heart disease in Koreans without diabetes, with a stronger association observed in women.
Park et al. (2021) conducted a cohort in Without diabetes (n=16,455). Triglyceride to HDL-Cholesterol Ratio (TG/HDL-C) vs. Lowest TG/HDL-C quartile was evaluated on Incident ischemic heart disease (IHD) (HR 2.29, 95% CI 1.50-3.51, p=<0.001). An increased triglyceride to HDL-cholesterol ratio in the highest quartile was associated with a 2.29-fold higher risk of incident ischemic heart disease compared to the lowest quartile in Koreans without diabetes.
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