Key result
Implementation of service changes, including point-of-care INR testing, reduced median scan-to-needle time for prothrombin complex concentrate from 127 minutes to 58 minutes (p<0.001).
Why the study?
Do service changes including point-of-care INR testing and autonomous administration protocols reduce the time to PCC administration in patients with VKA-ICH?
Population
55 patients with intracerebral haemorrhage taking vitamin K antagonists admitted on the acute stroke…
Comparison
Service changes implemented during 2011/12… vs Standard care prior to service changes.
Design
Cohort
Authors
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May accelerate PCC reversal in VKA-ICH; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=55)
No
Do service changes including point-of-care INR testing and autonomous administration protocols reduce the time to PCC administration in patients with VKA-ICH?
Absolute Event Rate: 58% vs 127%
p-value: p=<0.001
Implementing point-of-care INR testing, ED storage of PCC, and autonomous administration protocols significantly reduces delays in reversing anticoagulation for VKA-ICH patients.
Adrian Parry‐Jones (2015) conducted a cohort in Intracerebral haemorrhage in patients taking vitamin K antagonists (VKA-ICH) (n=55). Service changes (point-of-care INR testing, PCC in emergency department, autonomous administration protocol) vs. Prior to service changes was evaluated on Time interval between diagnostic brain scan and commencement of PCC treatment (scan-to-needle time) (p=<0.001). Implementation of service changes, including point-of-care INR testing, reduced median scan-to-needle time for prothrombin complex concentrate from 127 minutes to 58 minutes (p<0.001).
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