What question did this study set out to answer?

To determine the extent of sequence conservation and structural diversity in the outer membrane protein P2 across multiple nontypeable Haemophilus influenzae isolates.

June 1, 1994Infection and ImmunityOpen Access

Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates

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Authors

JBJ I BellStanford University SGSusan GrassDuke University DJDenis JeanteurProtein Research Foundation

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Implication

Comparative sequence analysis reveals localized surface-loop diversity in nontypeable Haemophilus influenzae P2 proteins, highlighting potential challenges for universal vaccine design.

Key Points

To determine the extent of sequence conservation and structural diversity in the outer membrane protein P2 across multiple nontypeable Haemophilus influenzae isolates.
Cloned and sequenced outer membrane protein P2 genes from four nontypeable Haemophilus influenzae strains.
Compared deduced P2 amino acid sequences with outer membrane protein P2 sequences from Haemophilus influenzae type b MinnA and three additional nontypeable strains.
Deduced P2 amino acid sequences shared between 76% and 94% identity across the evaluated strains.
Identified regions of marked sequence variability flanked by highly conserved segments, with variable domains mapping directly to putative surface-exposed protein loops.

Cite This Study

Bell et al. (1994) studied this question.

synapsesocial.com/papers/6a77266e137c7dcc81bda52d https://doi.org/10.1128/iai.62.6.2639-2643.1994

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Implication

Comparative sequence analysis reveals localized surface-loop diversity in nontypeable Haemophilus influenzae P2 proteins, highlighting potential challenges for universal vaccine design.

Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates

Discussion

Member takes

Implication

Key Points

Cite This Study

Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider