Key result
Renin-angiotensin-aldosterone system polymorphisms, including specific AGT haplotypes, were significantly associated with an increased risk of atherosclerotic stroke in Tunisians.
Why the study?
Are renin-angiotensin-aldosterone system polymorphisms associated with the risk of atherosclerotic stroke in Tunisians?
Case-Control (n=773)
Are renin-angiotensin-aldosterone system polymorphisms associated with the risk of atherosclerotic stroke in Tunisians?
Specific angiotensinogen haplotypes are significantly associated with an increased risk of atherosclerotic ischemic stroke in the Tunisian population.
RAAS variants should not yet alter stroke risk assessment in Tunisians; leaves open ancestry-specific causality pending prospective validation.
OBJECTIVE: The association of renin C-4063T and angiotensinogen (AGT) T174M, AGT M235T and AGT A-6G polymorphisms with ischemic stroke of atherosclerotic etiology was investigated in 329 Tunisian patients with stroke and 444 controls. MATERIALS AND METHODS: Genotyping was performed using PCR-RFLP and the contributions of polymorphisms to the risk of stroke were analyzed using haplotype and multivariate regression analysis. RESULTS: AGT 235T and AGT-6G allele and AGT 235T/T, AGT-6A/G and AGT-6G/G genotype frequencies were higher in patients. Linkage disequilibrium (LD) was noted for AGT174T with AGT235M and AGT(-6)A in patients, while AGT235M was in LD with AGT(-6)A in controls and AGT235T was in LD with AGT(-6)G in both groups. The AGT 174T/235T/-6A and AGT 174T/235M/-6G haplotypes were positively and negatively associated with stroke respectively. Multivariate regression analysis identified AGT 174T/235M/-6A, AGT 174T/235T/-6G, AGT 174T/235T/-6A and AGT 174M/235T/-6A haplotypes to be significantly associated with an increased risk of stroke. CONCLUSIONS: Renin-angiotensin-aldosterone system polymorphisms influence the risk of atherosclerotic stroke in Tunisians.
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Saidi et al. (2009) conducted a case-control in Ischemic stroke of atherosclerotic etiology (n=773). Renin-angiotensin-aldosterone system polymorphisms (renin C-4063T, AGT T174M, AGT M235T, AGT A-6G) vs. Controls (without stroke) was evaluated on Risk of ischemic stroke of atherosclerotic etiology. Renin-angiotensin-aldosterone system polymorphisms, including specific AGT haplotypes, were significantly associated with an increased risk of atherosclerotic stroke in Tunisians.
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