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September 20, 2010Genetic Testing and Molecular Biomarkers

Evaluation of the Contribution of Renin Angiotensin System Polymorphisms to the Risk of Coronary Artery Disease Among Tunisians

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Why the study?

Are renin-angiotensin system gene polymorphisms associated with an increased risk of coronary artery disease in the Tunisian population?

Population

657 Tunisians, comprising 341 patients with coronary artery disease and 316 age- and sex-matched healthy…

Comparison

Presence of renin-angiotensin system gene… vs Healthy controls without coronary artery disease

Design

Case-control

Authors

NANesrine AbboudCentre National de la Recherche ScientifiqueLGLakhder GhazouaniBKBelhassen KâabiInstitut Pasteur de Tunis

Discussion

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Implication

These polymorphisms were associated with CAD in Tunisians; leaves open validation in prospective cohorts before any clinical use.

Structured PICO

Are renin-angiotensin system gene polymorphisms associated with an increased risk of coronary artery disease in the Tunisian population?

P
Population
657 Tunisians, comprising 341 patients with coronary artery disease (CAD) and 316 age- and sex-matched healthy controls.
I
Intervention
Presence of renin-angiotensin system gene polymorphisms (ACE Ins/Del, angiotensinogen T174M and M235T, and angiotensin II type 1 receptor A1166C)
C
Comparator
Healthy controls without coronary artery disease
O
Outcome
Presence of coronary artery disease (CAD)

Specific renin-angiotensin system gene polymorphisms (ACE Ins/Del, M235T, and T174M) are associated with an increased risk of coronary artery disease in the Tunisian population.

Cite This Study

Abboud et al. (2010) studied this question.

synapsesocial.com/papers/6a911eb4ea479158cc70ff13https://doi.org/10.1089/gtmb.2010.0070
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Also Consider

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  1. 1Heart failure and neuroendocrine activation: diagnostic, prognostic and therapeutic perspectives2001 · 129 citations
  2. 2Minireview: Overview of the Renin-Angiotensin System—An Endocrine and Paracrine System2003 · 580 citations
  3. 3Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction but Not With Development of Coronary Stenosis1995 · 175 citations
  4. 4Angiotensin-Converting Enzyme Genotype in Children and Coronary Events in Their Grandparents1995 · 66 citations
  5. 5Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese.1994 · 275 citations