Key result
Under a dominant model, the adiponectin +45 T>G polymorphism was associated with an increased risk of CAD (OR 2.59; 95% CI 1.17-5.70; P=0.01), while +276 G>T was associated with a decreased risk.
Why the study?
Are adiponectin gene SNPs +45 T>G and +276 G>T associated with the risk of coronary artery disease in a Tunisian population?
Case-Control (n=546)
Are adiponectin gene SNPs +45 T>G and +276 G>T associated with the risk of coronary artery disease in a Tunisian population?
Odds Ratio: 2.59 (95% CI 1.17–5.7)
p-value: p=0.01
While overall allelic distributions did not differ, dominant model logistic regression suggests adiponectin SNPs +45 T>G and +276 G>T may modulate CAD risk in a Tunisian population.
Adiponectin variants may influence CAD susceptibility; hypothesis-generating observation requiring validation before any clinical use.
BACKGROUND: Adiponectin, an adipocyte-derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti-atherogenic, anti-inflammatory, antioxidative, and anti-apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North-African population from Tunisia. METHODS: Subjects comprised 277 patients with angiographically demonstrated CAD and 269 age- and gender-matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis. RESULTS: Adiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17-5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22-0.97); P = .04]. CONCLUSION: There is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population.
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Ghazouani et al. (2018) conducted a case-control in Coronary artery disease (CAD) (n=546). Adiponectin gene polymorphisms +45 T>G and +276 G>T vs. Age- and gender-matched control subjects was evaluated on Risk of developing CAD (OR 2.59, 95% CI 1.17-5.70, p=0.01). Under a dominant model, the adiponectin +45 T>G polymorphism was associated with an increased risk of CAD (OR 2.59; 95% CI 1.17-5.70; P=0.01), while +276 G>T was associated with a decreased risk.
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