Key result
Adiponectin gene single-nucleotide polymorphisms +45 T>G and +276 G>T were not significantly associated with coronary artery disease or coronary slow flow (p=0.464 and p=0.624 for genotypes).
Why the study?
The study was conducted to investigate the association of two adiponectin gene single-nucleotide polymorphisms (+45 T>G and +276 G>T) in patients with coronary artery disease, coronary slow flow, and healthy subjects.
Are adiponectin gene single-nucleotide polymorphisms (+45 T>G and +276 G>T) associated with coronary artery disease or coronary slow flow?
Observational (n=90)
Are adiponectin gene single-nucleotide polymorphisms (+45 T>G and +276 G>T) associated with coronary artery disease or coronary slow flow?
p-value: p=0.464
The adiponectin gene single-nucleotide polymorphisms +45 T>G and +276 G>T do not appear to be associated with coronary artery disease or coronary slow flow.
Aim To investigate the association of two single-nucleotide polymorphisms (SNPs) of the adiponectin gene (+45 T>G [rs2241766] and +276 G>T [rs1501299]) in patients with coronary artery disease (CAD), coronary slow flow (CSF) and in healthy subjects. Methods The study investigated 90 patients: 30 patients with coronary artery disease (the CAD group), 30 with only coronary slow flow (the CSF group) and 30 healthy patients. Genotyping was carried out for two of these SNPs in the adiponectin gene using the TaqMan polymerase chain reaction (PCR) method. Results There were no significant differences in the frequencies of polymorphism +45T>G (rs2241766) genotype (p=0.464) and the allele (p=0.362). There were also no significant differences between the +276 G>T (rs1501299) genotype and the allele (p=0.624 and p=0.281, respectively). Conclusion Our study indicated that in patients with CAD, CSF, and in healthy subjects, the SNP +276G>T and +45T>G alleles of the adiponectin gene were not associated.
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Diah et al. (2020) conducted an observational in Coronary artery disease and coronary slow flow (n=90). Adiponectin gene SNPs (+45 T>G and +276 G>T) vs. Healthy subjects was evaluated on Frequencies of polymorphism +45T>G and +276 G>T genotypes and alleles (p=0.464). Adiponectin gene single-nucleotide polymorphisms +45 T>G and +276 G>T were not significantly associated with coronary artery disease or coronary slow flow (p=0.464 and p=0.624 for genotypes).
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