Key result
Adiponectin rs266729 G allele linked to ~30% higher CAD risk in females.
Why the study?
The association between adiponectin gene polymorphisms and coronary artery disease in a Chinese population was unclear.
Are adiponectin gene polymorphisms (rs822395 and rs266729) associated with the occurrence and severity of coronary artery disease in a Chinese population?
Case-Control (n=435)
Are adiponectin gene polymorphisms (rs822395 and rs266729) associated with the occurrence and severity of coronary artery disease in a Chinese population?
The adiponectin gene rs266729 variant demonstrates a gender-specific effect, increasing the risk of coronary artery disease in Chinese women.
Answers are grounded in this paper and cite their sources.
rs266729 G allele was associated with CAD risk in Chinese women; hypothesis-generating finding leaves open any broader role in CAD susceptibility.
We investigated the association between two single nucleotide polymorphisms (SNPs) in the adiponectin gene (rs822395 and rs266729) and coronary artery disease (CAD) in a case-control study of 198 unrelated Chinese CAD patients (with ≥ 70% coronary stenosis or previous myocardial infarction) and 237 non-CAD controls. The ligase reaction was used to detect SNPs rs822395 and rs266729, and the allelic association of these SNPs with the occurrence and severity of CAD was assessed. There were no significant differences in the genotypic or allelic frequencies of the two SNPs between control and CAD individuals. In addition, there was no association between the two SNPs and the severity of CAD based on the number of diseased vessels. The frequencies of alleles C and G at rs266729 differed significantly between females in the CAD and control groups, but not between males. Female carriers of allele G at rs266729 had a higher risk of CAD compared with allele C carriers (OR = 1.30, 95% CI: 1.09-2.64, p = 0.02). These results indicate a gender-specific effect of the adiponectin gene rs266729 variant in modulating the risk of CAD in women.
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Zhen et al. (2010) conducted a case-control in Coronary artery disease (n=435). Adiponectin gene polymorphisms (rs822395 and rs266729) vs. Non-CAD controls / Allele C carriers was evaluated on Occurrence and severity of CAD (OR 1.30, 95% CI 1.09-2.64, p=0.02). Female carriers of the adiponectin gene rs266729 allele G had a higher risk of coronary artery disease compared with allele C carriers (OR 1.30; 95% CI 1.09-2.64; p=0.02).
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