What question did this study set out to answer?

To investigate whether the +45T>G and +276G>T single nucleotide polymorphisms at the adiponectin gene locus determine coronary artery disease risk in patients with type 2 diabetes.

August 1, 2004Diabetes CareOpen Access

The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients

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Why the study?

Are the +45T>G and +276G>T single nucleotide polymorphisms of the adiponectin gene associated with coronary artery disease in type 2 diabetic patients?

Key Points

To investigate whether the +45T>G and +276G>T single nucleotide polymorphisms at the adiponectin gene locus determine coronary artery disease risk in patients with type 2 diabetes.
Studied 376 consecutive type 2 diabetic patients, comprising 142 cases (coronary stenosis >50% or prior myocardial infarction) and 234 controls (no symptoms/ischemia signs and normal stress test or stenosis ≤50%).
Genotyped participants for adiponectin locus SNPs (+45T>G and +276G>T) and quantified circulating serum adiponectin concentrations.
The +276 T/T genotype was significantly associated with reduced CAD risk compared to other genotypes (adjusted OR 0.13, 95% CI 0.037–0.46, P = 0.002), with similar protection observed in angiographically verified subjects (OR 0.04, 95% CI 0.006–0.30, P = 0.002).
No association with CAD was found for the +45 SNP (P = 0.48), and serum adiponectin levels did not significantly differ between CAD cases and controls (25 ± 13 vs. 26 ± 17 µg/ml).

Structured PICO

Are the +45T>G and +276G>T single nucleotide polymorphisms of the adiponectin gene associated with coronary artery disease in type 2 diabetic patients?

Population

376 consecutive type 2 diabetic patients: 142 case subjects with coronary stenosis >50% or previous myocardial infarction and 234 control subjects with no symptoms, no electrocardiogram (ECG) signs of myocardial ischemia, and a normal ECG stress test (n = 189) and/or (n = 45) with coronary stenosis <=50%.

Intervention

Adiponectin gene single nucleotide polymorphisms (+45T>G and +276G>T)

Comparator

Different genotypes (e.g., T/T homozygotes vs carriers of other genotypes)

Outcome

Coronary artery disease (CAD)hard clinical

The +276 G>T polymorphism of the adiponectin gene is a significant determinant of CAD risk in type 2 diabetic patients, with the T/T genotype conferring a protective effect.

Discussion

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Implication

+276 T/T genotype associated with lower CAD risk in T2D; leaves open clinical utility of genotyping pending prospective validation.

Cite This Study

Bacci et al. (2004) studied this question.

synapsesocial.com/papers/6a70fbc98031ec7bb1dcb3bf https://doi.org/10.2337/diacare.27.8.2015

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The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients

Key Points

Structured PICO

Discussion

Implication

Cite This Study

The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider