June 21, 2004Diabetic Medicine
The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non‐insulin‐dependent) diabetes mellitus
Why the study?
Is the APM1 gene SNP+45 T>G associated with coronary artery disease in Caucasian Type 2 diabetic patients?
Population
477 Caucasian Type 2 diabetic patients (162 with coronary artery disease, 315 without coronary artery disease)
Comparison
APM1 gene single nucleotide polymorphisms vs Absence of SNP+45 T>G / wild-type alleles
Design
Case-control
Authors
Discussion
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Member takes
Implication
SNP+45 T>G may support CAD risk assessment in T2D; leaves open validation in prospective cohorts before clinical use.
Structured PICO
Is the APM1 gene SNP+45 T>G associated with coronary artery disease in Caucasian Type 2 diabetic patients?
P
Population
477 Caucasian Type 2 diabetic patients (162 with coronary artery disease, 315 without coronary artery disease)
I
Intervention
APM1 gene single nucleotide polymorphisms (specifically SNP+45 T>G)
C
Comparator
Absence of SNP+45 T>G / wild-type alleles
O
Outcome
Presence of coronary artery disease (CAD)hard clinical
The APM1 gene SNP+45 T>G is associated with an increased susceptibility to coronary artery disease in Caucasian patients with Type 2 diabetes, independent of classic cardiovascular risk factors.
Cite This Study
Lacquemant et al. (2004) studied this question.