Key result
Homozygosity for a common haplotype at the ADIPOR1 locus was associated with a significantly increased risk of coronary artery disease in patients with type 2 diabetes (OR 3.6; 95% CI 1.8-7.2).
Why the study?
Are common haplotypes at the ADIPOR1 locus associated with increased risk of coronary artery disease in patients with type 2 diabetes?
Case-Control (n=944)
Yes
Are common haplotypes at the ADIPOR1 locus associated with increased risk of coronary artery disease in patients with type 2 diabetes?
Odds Ratio: 3.6 (95% CI 1.8–7.2)
p-value: p=0.0002
Genetic variability at the ADIPOR1 locus is a strong determinant of coronary artery disease susceptibility in patients with type 2 diabetes.
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Does not support ADIPOR1 genotyping for CAD risk assessment in T2D; hypothesis-generating for replication and mechanistic studies.
Soccio et al. (2006) conducted a case-control in Coronary artery disease in type 2 diabetes (n=944). Common haplotypes at the ADIPOR1 locus vs. Other haplotypes / non-carriers was evaluated on Coronary artery disease (OR 3.6, 95% CI 1.8-7.2, p=0.0002). Homozygosity for a common haplotype at the ADIPOR1 locus was associated with a significantly increased risk of coronary artery disease in patients with type 2 diabetes (OR 3.6; 95% CI 1.8-7.2).
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