Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study

540 overweight or obese individuals with impaired glucose tolerance or impaired fasting glycemia (484 from the Finnish Diabetes Prevention Study [DPS] and 56 from the Genobin study), mean age 55.2 years (DPS) and 59.4 years (Genobin). Key inclusion for DPS: BMI ≥25 kg/m2, aged 40-64 years, impaired glucose tolerance.

Presence of specific ADIPOR2 gene single nucleotide polymorphisms (SNPs)

Absence of specific ADIPOR2 gene single nucleotide polymorphisms (SNPs) / alternative genotypes

Cardiovascular disease morbidity and mortality (fatal and non-fatal acute coronary events, coronary heart disease, stroke, and hypertensive disease) at median 10.2 years follow-up, and conversion from IGT to T2DM at median 7 years follow-uphard clinical