Key result
Although 14 ADIPOR1 sequence variants (minor allele frequency >5%) showed no association with type 2 diabetes, ADIPOR1 mRNA levels were significantly lower in diabetic African-American lymphocytes.
Why the study?
Do sequence variations in the ADIPOR1 gene contribute to the risk of developing type 2 diabetes and metabolic syndrome?
Observational
Do sequence variations in the ADIPOR1 gene contribute to the risk of developing type 2 diabetes and metabolic syndrome?
While ADIPOR1 SNPs are not directly associated with type 2 diabetes, altered ADIPOR1 gene expression may play a role in the metabolic syndrome.
No takes yet. Share an insight, caveat, or question.
ADIPOR1 variants unlikely to inform type 2 diabetes risk assessment; lower expression in diabetics leaves open a role for transcriptional regulation in metabolic syndrome.
Wang et al. (2004) conducted an observational in Type 2 diabetes and metabolic syndrome. ADIPOR1 gene sequence variations vs. Control cell lines was evaluated on Association with type 2 diabetes, insulin sensitivity, and insulin secretion. Although 14 ADIPOR1 sequence variants (minor allele frequency >5%) showed no association with type 2 diabetes, ADIPOR1 mRNA levels were significantly lower in diabetic African-American lymphocytes.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: