Key result
The ADIPOR1 variant rs3737884-G was significantly associated with an increased risk of comorbid type 2 diabetes and coronary artery disease (OR 2.42).
Why the study?
Do ADIPOR1 gene polymorphisms increase the risk of Type 2 Diabetes, Coronary Artery Disease, and their comorbidity in a Northern Han Chinese population?
Case-Control (n=657)
Yes
Do ADIPOR1 gene polymorphisms increase the risk of Type 2 Diabetes, Coronary Artery Disease, and their comorbidity in a Northern Han Chinese population?
Odds Ratio: 2.42 (95% CI 1.51–3.89)
p-value: p=2.48x10^-4
ADIPOR1 risk variants rs3737884-G and rs16850797-C are associated with increased susceptibility to T2D, CAD, and their comorbidity in a Northern Han Chinese population, supporting a shared genetic basis for these metabolic and cardiovascular diseases.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice; extends genetic association evidence to Northern Han Chinese with comorbid T2D-CAD.
Jin et al. (2014) conducted a case-control in Type 2 Diabetes and Coronary Artery Disease (n=657). ADIPOR1 gene variants (rs3737884-G) vs. Healthy controls (non-risk alleles) was evaluated on Risk of comorbid Type 2 Diabetes and Coronary Artery Disease (T2D+CAD) (OR 2.42, 95% CI 1.51-3.89, p=2.48x10^-4). The ADIPOR1 variant rs3737884-G was significantly associated with an increased risk of comorbid type 2 diabetes and coronary artery disease (OR 2.42).
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