Why the study?
Do genetic polymorphisms in the renin-angiotensin system (AT1R and ACE genes) increase the risk of stroke in a population-based cohort?
Population
824 individuals from northern Sweden, comprising 275 who suffered a first ever stroke during follow-up and…
Comparison
AA genotype of the AT1R gene and D allele of the… vs AC and CC genotypes of the AT1R gene; non-D…
Design
Case-control
Authors
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May elevate stroke risk beyond traditional factors; hypothesis-generating, requiring prospective validation before any clinical use.
Do genetic polymorphisms in the renin-angiotensin system (AT1R and ACE genes) increase the risk of stroke in a population-based cohort?
Polymorphisms in the renin-angiotensin system (AT1R A1166C and ACE I/D) confer an increased risk of stroke independent of traditional risk factors like blood pressure.
Möllsten et al. (2008) studied this question.
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