Why the study?
Does the angiotensin II type 1 receptor A1166C polymorphism affect the risk of new-onset hypertension, blood pressure control, or incident cardiovascular events in older adults?
Population
2,171 older adults in the Cardiovascular Health Study
Comparison
Angiotensin II type 1 receptor A1166C polymorphism vs AA or AC genotype
Design
Cohort
Follow-up
median 8.1 years
Authors
Loading...
No role for A1166C genotyping in older-adult hypertension management; leaves open subgroup or pharmacogenomic effects.
Does the angiotensin II type 1 receptor A1166C polymorphism affect the risk of new-onset hypertension, blood pressure control, or incident cardiovascular events in older adults?
The A1166C polymorphism of the angiotensin II type 1 receptor is not significantly associated with blood pressure control or incident cardiovascular events in the general older adult population.
Lucia A. Hindorff (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: