Key result
AT1R A1166C polymorphism is not significantly associated with higher blood pressure vs wild type.
Why the study?
The A1166C (rs5186) single nucleotide polymorphism in the angiotensin II type 1 receptor (AT1R) gene is associated with an increased risk of hypertension through structural changes and microRNA expression. This study aimed to explore the effect of the AT1R A1166C polymorphism on blood pressure levels in hypertensive patients.
Does the AT1R A1166C gene polymorphism increase systolic and diastolic blood pressure levels compared to wild type in patients with hypertension?
Cross-Sectional (n=52)
Does the AT1R A1166C gene polymorphism increase systolic and diastolic blood pressure levels compared to wild type in patients with hypertension?
In this small cross-sectional cohort of hypertensive patients, the AT1R A1166C gene polymorphism was not statistically associated with elevated systolic or diastolic blood pressure compared to the wild type.
AT1R A1166C SNP shows no BP association; does not support genotyping for risk stratification and leaves open larger studies.
Background: Hypertension is a condition characterized by elevated blood pressure, posing a risk factor for various cardiovascular diseases (CVDs) with increasing prevalence worldwide. One risk factor for hypertension includes single nucleotide polymorphism (SNP) A1166C (rs5186) in angiotensin II type 1 receptor (AT1R) gene. Through a mechanism of structural changes and microRNA (miRNA) expression, A1166C SNP is associated with an increased risk of hypertension. Objective: This study aimed to explore the effect of AT1R A1166C SNP on blood pressure in hypertensive patients. Methods: The analytical cross-sectional observational study was carried out using primary data from 52 stored biological samples (peripheral blood mononuclear cells - PBMC) obtained from hypertensive patients. The variables measured were the presence of AT1R SNP and patients’ blood pressure. AT1R SNP was detected using polymerase chain reaction (PCR), followed by gene sequencing. Data analysis was conducted using T-test and Mann-Whitney tests for systolic blood pressure (SBP) and diastolic blood pressure (DBP). Result: There was no statistically significant difference in SBP and DBP among patients between AT1R A1166C SNP and wild type (WT) group (p > 0.05). However, a clinically meaningful difference in SBP was observed in AT1R A1166C SNP group (158±26) compared to WT group (144±22). Conclusion: AT1R A1166C SNP was not associated with increased blood pressure in this population.
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Tjipta et al. (2026) conducted a cross-sectional in Hypertension (n=52). AT1R A1166C SNP (rs5186) vs. Wild type (WT) AT1R was evaluated on Systolic blood pressure (SBP) and diastolic blood pressure (DBP) (p=>0.05). AT1R A1166C SNP was not significantly associated with higher blood pressure compared to wild type (SBP 158±26 vs 144±22 mmHg; p>0.05).
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