Key result
Higher serum levels of IGF-1 in the oldest old were associated with reduced carotid intima-media thickness, fewer carotid plaques, and greater walking speed.
Why the study?
Do physiological levels of IGF-1 associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old?
Cross-Sectional (n=100)
Do physiological levels of IGF-1 associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old?
Middle to higher serum levels of IGF-1 are associated with a territory-dependent atheroprotective phenotype and better physical fitness in the oldest old.
No immediate clinical implications; hypothesis-generating for IGF-1 in vascular aging and mobility among oldest old.
Our aim was to investigate whether physiological levels of soluble insulin-like growth factor-1 (IGF-1) associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old by means of a cross-sectional study including 100 community-dwelling individuals with no previous cardiovascular events. Linear correlation was found between IGF-1 and intima-media thickness, number of carotid plaques, and walking speed. Individuals in the upper IGF-1 tertile had smaller right and left intima-media thickness compared with the intermediate and lower tertiles, along with reduced atherosclerotic plaques. Also, walking speed was greater in the upper IGF-1 tertile. On the other hand, a nonlinear correlation was observed between IGF-1 and coronary calcification scores, with the intermediate IGF-1 tertile associated to the lowest scores of calcification and participants with lower circulating levels of IGF-1 showing higher frequency of high-risk morphology plaques. All in all, our report supports a territory-dependent, atherorefractory phenotype in the oldest old carrying middle and/or higher serum levels of IGF-1.
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Córdova et al. (2015) conducted a cross-sectional in Atherosclerotic burden in the oldest old (n=100). Serum IGF-1 levels vs. Lower IGF-1 tertiles was evaluated on Coronary and carotid atherosclerotic burden and physical fitness. Higher serum levels of IGF-1 in the oldest old were associated with reduced carotid intima-media thickness, fewer carotid plaques, and greater walking speed.
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