Key result
Fasting serum free IGF-I correlated inversely with carotid intima-media thickness (accounting for 5% of variation), whereas IGFBP-1 correlated positively (accounting for 6% of variation).
Cross-Sectional (n=96)
Serum free IGF-I and IGFBP-1 levels are associated with early signs of carotid atherosclerosis in healthy middle-aged men.
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These modest IGF axis correlations with intima-media thickness are hypothesis-generating; prospective studies needed to clarify clinical relevance.
Boquist et al. (2007) conducted a cross-sectional in Healthy (n=96). Serum IGF-I, IGFBP-1 and IGFBP-3 was evaluated on Common carotid intima-media thickness (IMT). Fasting serum free IGF-I correlated inversely with carotid intima-media thickness (accounting for 5% of variation), whereas IGFBP-1 correlated positively (accounting for 6% of variation).
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