Key result
Lower circulating IGFBP-1 concentrations are associated with an unfavorable cardiometabolic risk profile, while higher IGFBP-1 predicts worse cardiovascular disease outcomes.
Why the study?
Lower circulating IGFBP-1 is linked to unfavorable cardiometabolic risk profiles whereas higher levels predict worse cardiovascular outcomes, prompting an exploration of these associations and its role in atherosclerosis.
IGFBP-1 has a complex relationship with cardiovascular disease, where low levels associate with cardiometabolic risk but high levels predict worse outcomes, suggesting a need for dynamic multi-marker evaluation approaches.
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Lower IGFBP-1 may mark higher cardiometabolic risk; leaves open causal inference and any role in risk stratification.
Lewitt et al. (2024) conducted a review in Cardiovascular Disease. Insulin-like Growth Factor-Binding Protein-1 (IGFBP-1) was evaluated. Lower circulating IGFBP-1 concentrations are associated with an unfavorable cardiometabolic risk profile, while higher IGFBP-1 predicts worse cardiovascular disease outcomes.
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